Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atp1a4tm1Itl
Name:	ATPase, Na+/K+ transporting, alpha 4 polypeptide; targeted mutation 1, inGenious Targeting Laboratory
MGI ID:	MGI:4941050
Synonyms:	Atp1a4tm1Igl
Gene:	Atp1a4  Location: Chr1:172051080-172085981 bp, - strand  Genetic Position: Chr1, 79.54 cM
Alliance:	Atp1a4tm1Itl page

Germline Transmission:	Earliest citation of germline transmission: J:169420
Parent Cell Line:	iTL BA1 (ES Cell)
Strain of Origin:	(C57BL/6NTac x 129S6/SvEvTac)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exons 5 through 8 were replaced with a neo cassette. Sperm lack sodium-potassium ATPase activity. (J:169420)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a4 Mutation:	48 strains or lines available

Original:	J:169420 Jimenez T, et al., Na,K-ATPase alpha4 isoform is essential for sperm fertility. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):644-9
All:	2 reference(s)