Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nedd4ltm1.1Hkb
Name:	neural precursor cell expressed, developmentally down-regulated gene 4-like; targeted mutation 1.1, Hiroshi Kawabe
MGI ID:	MGI:4940977
Synonyms:	Nedd4-2f, Nedd4Lf, Nedd4ltm1.1Dro
Gene:	Nedd4l  Location: Chr18:65020776-65350899 bp, + strand  Genetic Position: Chr18, 37.57 cM, cytoband E1
Alliance:	Nedd4ltm1.1Hkb page

Germline Transmission:	Earliest citation of germline transmission: J:169296
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 15. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 15. Flp-mediated recombination removed the neo cassette leaving exon 15 floxed. (J:169296)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nedd4l Mutation:	71 strains or lines available

Original:	J:169296 Kimura T, et al., Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3216-21
All:	8 reference(s)