Il17atm1.1(icre)Stck
Targeted Allele Detail
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Symbol: |
Il17atm1.1(icre)Stck |
Name: |
interleukin 17A; targeted mutation 1.1, Brigitta Stockinger |
MGI ID: |
MGI:4940851 |
Synonyms: |
Il17aCre |
Gene: |
Il17a Location: Chr1:20801129-20804720 bp, + strand Genetic Position: Chr1, 6.45 cM, cytoband A
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Alliance: |
Il17atm1.1(icre)Stck page
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Allele Type: |
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Targeted (Null/knockout, Recombinase) |
Mutations: |
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Insertion, Nucleotide substitutions
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Il17atm1.1(icre)Stck expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Il17a (MGI:107364) |
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Mutation details: A codon-improved cre recombinase gene, preceded by a 5-codon linker sequence and followed by an SV40 intron and poly(A) signal sequences, was inserted immediately after the endogenous start codon in exon 1. Point mutations were introduced into exon 2 of the Il17a gene to disable an internal ATG-site. The neomycin resistance gene cassette that was inserted downstrea of the cre gene was excised by FLPe-mediated recombination to generate the the final allele.
(J:169305)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Il17a
(mouse)
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Original: |
J:169305 Hirota K, et al., Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol. 2011 Mar;12(3):255-63 |
All: |
68 reference(s) |
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