Summary | Transgene origin | Transgene description | Find Mice (IMSR) | Notes | References

Symbol:	Tg(Zap70*M413A)2Weis
Name:	transgene insertion 2, Arthur Weiss
MGI ID:	MGI:4940364
Synonyms:	Zap70(AS)
Transgene:	Tg(Zap70*M413A)2Weis  Location: unknown
Alliance:	Tg(Zap70*M413A)2Weis page

Germline Transmission:	Earliest citation of germline transmission: J:167326
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	B6;129X1-Zap70tm1Weis/AnuApb

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Zap70*M413A)2Weis expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Zap70 (MGI:99613)   Mutation details: Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a BAC (#RP23-6m17) containing the entire mouse zeta-chain (TCR) associated protein kinase (Zap70) gene. A point mutation was introduced in exon 8, resulting in the substitution of a methionine for an alanine (M413A). (J:167326)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:167326 Au-Yeung BB, et al., A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol. 2010 Dec;11(12):1085-92
All:	5 reference(s)