Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gnao1tm3Lbi
Name:	guanine nucleotide binding protein, alpha O; targeted mutation 3, Lutz Birnbaumer
MGI ID:	MGI:4889047
Synonyms:	Go2alpha-
Gene:	Gnao1  Location: Chr8:94536781-94696016 bp, + strand  Genetic Position: Chr8, 45.94 cM
Alliance:	Gnao1tm3Lbi page

Germline Transmission:	Earliest citation of germline transmission: J:168245
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A stop codon was inserted at cysteine position 255 in a duplicated exon 7.2 using a "hit and run" targeting strategy. The absence of protein product in brain and pancreatic islets was confirmed immunologically. (J:168245)

Generation of the Gnao1tm3Lbi allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:	29 strains or lines available

Original:	J:168245 Wang Y, et al., Augmented glucose-induced insulin release in mice lacking Go2, but not Go1 or Gi proteins. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1693-8
All:	1 reference(s)