Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itgaltm1.1Mshi
Name:	integrin alpha L; targeted mutation 1.1, Motomu Shimaoka
MGI ID:	MGI:4888587
Synonyms:	ItgalI306A, Itgaltm1(I306A)Mshi
Gene:	Itgal  Location: Chr7:126895432-126934310 bp, + strand  Genetic Position: Chr7, 69.44 cM
Alliance:	Itgaltm1.1Mshi page

Germline Transmission:	Earliest citation of germline transmission: J:168533
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector containing an I306A mutation in exon 9 and a self-excising loxP-flanked ACE (angiotensin-converting enzyme promoter)-cre-neomycin resistance cassette (also called ACN) in intron 9 was introduced to Bruce-4 C57BL/6-derived embryonic stem cells. Deletion of the floxed segment occurred during spermatogenesis, leaving a single loxP site. (J:168533)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgal Mutation:	74 strains or lines available

Original:	J:168533 Park EJ, et al., Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood. 2010 Feb 25;115(8):1572-81
All:	2 reference(s)