Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irx3tm1Hui
Name:	Iroquois related homeobox 3; targeted mutation 1, Chi-chung Hui
MGI ID:	MGI:4882110
Synonyms:	Irx3LacZ, Irx3tauLacZ
Gene:	Irx3  Location: Chr8:92525139-92528282 bp, - strand  Genetic Position: Chr8, 44.55 cM
Alliance:	Irx3tm1Hui page

Germline Transmission:	Earliest citation of germline transmission: J:168037
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding portion of exon 1 was replaced with a tauLacZ and an inverted HSV-neo cassette via homologous recombination. LacZ expression recapitulates endogenous gene expression. (J:175992)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irx3 Mutation:	24 strains or lines available

Original:	J:168037 Kim B, et al., Primordial germ cell proliferation is impaired in Fused Toes mutant embryos. Dev Biol. 2011 Jan 15;349(2):417-26
All:	10 reference(s)