Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Triobptm1Tbf
Name:	TRIO and F-actin binding protein; targeted mutation 1, Thomas B Friedman
MGI ID:	MGI:4881773
Synonyms:	Triobpdeltaexon8
Gene:	Triobp  Location: Chr15:78831924-78890069 bp, + strand  Genetic Position: Chr15, 37.7 cM
Alliance:	Triobptm1Tbf page

Germline Transmission:	Earliest citation of germline transmission: J:167947
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Modified isoform(s), Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Nearly all of exon 8 was replaced by a nlacZ reporter cassette and a floxed neo cassette, which was removed by cre-mediated recombination. The absence of isoform 5 transcript and isoform 4/5 proteins in the inner ear was confirmed by RT-PCR and western blot analysis respectively. Isoform 1 is retained. (J:167947)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Triobp Mutation:	74 strains or lines available

Original:	J:167947 Kitajiri S, et al., Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 2010 May 28;141(5):786-98
All:	4 reference(s)