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Tg(Pax4-cre)1Dam
Transgene Detail
Summary
Symbol: Tg(Pax4-cre)1Dam
Name: transgene insertion 1, Douglas A Melton
MGI ID: MGI:4868408
Synonyms: Pax4-Cre
Transgene: Tg(Pax4-cre)1Dam  Location: unknown  
Alliance: Tg(Pax4-cre)1Dam page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Pax4-cre)1Dam expression driven by 1 gene
 
Mutation details: The Pax4-cre transgene was designed with the mouse paired box gene 4 (Pax4) promoter directing expression of an enhanced green fluorescent protein fused to a tet-off cassette (EGFP/tTA). The transgene also contained a tetracycline-responsive element witha CMV minimal promoter (tetO-CMVmin) driving expression of a cre-recombinase. (J:119944)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pax4 (mouse)
Summary of all recombinase alleles driven by Pax4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
These Pax4-cre transgenic mice function only for cre recombinase expression in Pax4-expressing cells (no tet-Off or fluorescence function is reported). The transgene was microinjected into fertilized (C57BL/6 X CBA)F1 oocytes, and founder mice were bred to ICR outbred mice to establish a colony.
References
Original:  J:119944 Greenwood AL, et al., Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev. 2007 Feb;124(2):97-107
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory