Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Dchs1tm1.2Irv
Name:	dachsous cadherin related 1; targeted mutation 1.2, Kenneth Irvine
MGI ID:	MGI:4867020
Gene:	Dchs1  Location: Chr7:105402197-105436861 bp, - strand  Genetic Position: Chr7, 55.98 cM
Alliance:	Dchs1tm1.2Irv page

Germline Transmission:	Earliest citation of germline transmission: J:169135
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was flanked by loxP sites and preceded by a 5' FRT-flanked PGK-neomycin cassette. Flp-mediated recombination removed the neo cassette, and cre-mediated recombination removed exon 2. (J:169135)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dchs1 Mutation:	139 strains or lines available

Original:	J:169135 Mao Y, et al., Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011 Mar;138(5):947-57
All:	10 reference(s)