Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ackr4tm1.1Rjbn
Name:	atypical chemokine receptor 4; targeted mutation 1.1, Robert J B Nibbs
MGI ID:	MGI:4847614
Synonyms:	CCRL1-
Gene:	Ackr4  Location: Chr9:103974881-104003842 bp, - strand  Genetic Position: Chr9, 56.47 cM
Alliance:	Ackr4tm1.1Rjbn page

Germline Transmission:	Earliest citation of germline transmission: J:166490
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by RT-PCR on thymus and heart extracts. (J:166490)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ackr4 Mutation:	25 strains or lines available

Original:	J:166490 Comerford I, et al., The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses. Blood. 2010 Nov 18;116(20):4130-40
All:	13 reference(s)