Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ep400tm3Fuku Name: E1A binding protein p400; targeted mutation 3, Rikiro Fukunaga MGI ID: MGI:4845874 Synonyms: mDomfl Gene: Ep400  Location: Chr5:110812239-110918583 bp, - strand  Genetic Position: Chr5, 53.69 cM, cytoband F Alliance: Ep400tm3Fuku page

Loss of bone marrow hematopoietic cells in Ep400tm3Fuku/Ep400tm3.1Fuku Tg(Mx1-cre)1Cgn/0 mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:166397
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 15, and an FRT and loxP flanked neo cassette was inserted downstream of exon 15. Flp-mediated recombination removed the neo cassette leaving exon 15 floxed. (J:166397)

Generation of the Ep400tm3Fuku and Ep400tm3.1Fuku alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

10 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ep400 Mutation:	140 strains or lines available

Original:	J:166397 Fujii T, et al., Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression. J Biol Chem. 2010 Sep 24;285(39):30214-23
All:	4 reference(s)