Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pik3catm1.1Rzl
Name:	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1.1, Richard Z Lin
MGI ID:	MGI:4845856
Synonyms:	p110alphaflox, p110alphaFlox, pik3ca1 loxP, Pik3caFlox
Gene:	Pik3ca  Location: Chr3:32451203-32520256 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Alliance:	Pik3catm1.1Rzl page

Germline Transmission:	Earliest citation of germline transmission: J:166421
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1, and an FRT and loxP flanked neo cassette was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette leaving exon 1 floxed. (J:166421)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:	62 strains or lines available

Original:	J:166421 Lu Z, et al., Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction. Circulation. 2009 Jul 28;120(4):318-25
All:	11 reference(s)