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Gene Expression Data
Assay Details
Assay
Reference: J:150086 Kiso M, et al., The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9292-7
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:4844119
Gene symbol: Sox21
Gene name: SRY (sex determining region Y)-box 21
Reporter: GFP
Antibody: Anti-GFP (Santa Cruz)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2I & I', I'': postnatal day 5; Sox21tm1.1Ysa/Sox21+ (more )
Note: Double labeled: green - Sox21 reporter; red - Krt14 (assay MGI:4844111).
Structure Level Pattern Image Note
TS28: hair cuticle Present 2I' , 2I , 2I''
Specimen 2J & J', J'': postnatal day 5; Sox21tm1.1Ysa/Sox21tm1.1Ysa (more )
Note: Double labeled: green - Sox21 reporter; red - Krt14 (assay MGI:4844111).
Structure Level Pattern Image Note
TS28: hair cuticle Present 2J'' , 2J' , 2J
TS28: hair cortex Present 2J'' , 2J , 2J' Ectopic expression was detected in the cortex layer of the mutant.
Specimen 2K & K', K'': postnatal day 5; Sox21tm1.1Ysa/Sox21+ (more )
Note: Double labeled: green - Sox21 reporter; red - Krt71 (assay MGI:4844112).
Structure Level Pattern Image Note
TS28: hair cuticle Present 2K' , 2K , 2K''
Specimen 2L & L', L'': postnatal day 5; Sox21tm1.1Ysa/Sox21tm1.1Ysa (more )
Note: Double labeled: green - Sox21 reporter; red - Krt71 (assay MGI:4844112).
Structure Level Pattern Image Note
TS28: hair cuticle Present 2L'' , 2L , 2L'
TS28: hair cortex Present 2L , 2L' , 2L'' Ectopic expression was detected in the cortex layer of the mutant.
Specimen 2M & M', M'': postnatal day 5; Sox21tm1.1Ysa/Sox21+ (more )
Note: Double labeled: green - Sox21 reporter; red - Krt31 (assay MGI:4844116).
Structure Level Pattern Image Note
TS28: hair cuticle Present 2M'' , 2M , 2M'
Specimen 2N & N', N'': postnatal day 5; Sox21tm1.1Ysa/Sox21tm1.1Ysa (more )
Note: Double labeled: green - Sox21 reporter; red - Krt31 (assay MGI:4844116).
Structure Level Pattern Image Note
TS28: hair cuticle Present 2N' , 2N , 2N''
TS28: hair cortex Present 2N' , 2N , 2N'' Ectopic expression was detected in the cortex layer of the mutant.
Specimen S3C Sox21+/- P7: postnatal day 7; Sox21tm1.1Ysa/Sox21+ (more )
Note: Anagen phase. Double labeled: green - Sox21 reporter; red - Mki67 (assay MGI:4844279).
Structure Level Pattern Image Note
TS28: epidermis Present S3C Sox21+/- P7
Specimen S3C Sox21-/- P7: postnatal day 7; Sox21tm1.1Ysa/Sox21tm1.1Ysa (more )
Note: Anagen phase. Double labeled: green - Sox21 reporter; red - Mki67 (assay MGI:4844279).
Structure Level Pattern Image Note
TS28: epidermis Present S3C Sox21-/- P7
Specimen S3C Sox21+/- P15: postnatal day 15; Sox21tm1.1Ysa/Sox21+ (more )
Note: Catagen. Double labeled: green - Sox21 reporter; red - Mki67 (assay MGI:4844279).
Structure Level Pattern Image Note
TS28: epidermis Present S3C Sox21+/- P15
Specimen S3C Sox21-/- P15: postnatal day 15; Sox21tm1.1Ysa/Sox21tm1.1Ysa (more )
Note: Catagen. Double labeled: green - Sox21 reporter; red - Mki67 (assay MGI:4844279).
Structure Level Pattern Image Note
TS28: epidermis Present S3C Sox21-/- P15
Specimen S3C Sox21+/- P19: postnatal day 19; Sox21tm1.1Ysa/Sox21+ (more )
Note: Telogen phase. Double labeled: green - Sox21 reporter; red - Mki67 (assay MGI:4844279).
Structure Level Pattern Image Note
TS28: epidermis Present S3C Sox21+/- P19
Specimen S3C Sox21-/- P19: postnatal day 19; Sox21tm1.1Ysa/Sox21tm1.1Ysa (more )
Note: Telogen phase. Double labeled: green - Sox21 reporter; red - Mki67 (assay MGI:4844279).
Structure Level Pattern Image Note
TS28: epidermis Present S3C Sox21-/- P19
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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