Tg(Krt19-KRAS*G12V)AAru
Transgene Detail
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| Symbol: |
Tg(Krt19-KRAS*G12V)AAru |
| Name: |
transgene insertion A, Anil K Rustgi |
| MGI ID: |
MGI:4839478 |
| Synonyms: |
K19-kras |
| Transgene: |
Tg(Krt19-KRAS*G12V)AAru Location: unknown
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| Alliance: |
Tg(Krt19-KRAS*G12V)AAru page
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| Strain of Origin: |
C57BL/6 x SJL
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: A 2.1-kb genomic fragment of the 5'-flanking region/promoter of the mouse Keratin 19 gene drives expression of the full-length human K-ras gene with a point mutation in codon 12 that alters a Gly residue to a Val in the encoded protein. An intronic fragment from the rabbit beta-globin gene was inserted between the promoter and mutated KRAS gene to enhance gene expression. In addition to line A, lines B and C were also created.
(J:83092)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:83092 Brembeck FH, et al., The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. Cancer Res. 2003 May 1;63(9):2005-9 |
| All: |
3 reference(s) |
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Analysis Tools
