Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO-EDN1,-lacZ)9Mhus
Name:	transgene insertion 9, Mansoor Husain
MGI ID:	MGI:4837732
Synonyms:	ET-1
Transgene:	Tg(tetO-EDN1,-lacZ)9Mhus  Location: unknown
Alliance:	Tg(tetO-EDN1,-lacZ)9Mhus page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-EDN1,-lacZ)9Mhus expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human EDN1 (1906) Edn1  (MGI:95283)   Mutation details: The tetO-EDN1 transgene was designed with a bidirectional tetracycline operator (tetO; also called tetracycline-responsive element (TRE, TetRE) or tet-operator), pBi-1, between two cytomegalovirus (CMV) minimal promoters in the opposite orientation. One CMV promoter drives expression of the human endothelin (EDN1 or ET-1) gene, followed by a simian virus 40 (SV40) polyadenylation (polyA) signal, while the other drives expression of a beta-galactosidase (lacZ) reporter followed by a beta-globin polyA signal. Three lines were generated (9, 101, and 403). Line 9 exhibits high levels of expression in the myocardium. (J:131245)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:131245 Yang LL, et al., Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice. Circulation. 2004 Jan 20;109(2):255-61
All:	4 reference(s)