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Gene Expression Data
Assay Details
Assay
Reference: J:157948 Jiang XS, et al., Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications. Hum Mol Genet. 2010 Apr 1;19(7):1347-57
Assay type: Western blot
MGI Accession ID: MGI:4836617
Gene symbol: Cfl1
Gene name: cofilin 1, non-muscle
Antibody: Anti-Phospho-Cofilin-1 (Ser3)
Detection system: Secondary antibody coupled to alkaline phosphatase
Results Image: 1E P-Cofilin-1
 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified (a) Genetic BackgroundMutant Allele(s)Sex
E12.5 +/+ E12.5 TS20: brain Present involves: 129S4/SvJae Not Specified
E12.5 delta/delta E12.5 TS20: brain Present involves: 129S4/SvJae Dhcr7tm1Fdp/Dhcr7tm1FdpNot Specified
E14.5 +/+ E14.5 TS22: brain Present involves: 129S4/SvJae Not Specified
E14.5 delta/delta E14.5 TS22: brain Present involves: 129S4/SvJae Dhcr7tm1Fdp/Dhcr7tm1FdpNot Specified
E16.5 +/+ E16.5 TS24: brain Present involves: 129S4/SvJae Not Specified
E16.5 delta/delta E16.5 TS24: brain Present involves: 129S4/SvJae Dhcr7tm1Fdp/Dhcr7tm1FdpNot Specified
E18.5 +/+ E18.5 TS26: brain Present involves: 129S4/SvJae Not Specified
E18.5 delta/delta E18.5 TS26: brain Present involves: 129S4/SvJae Dhcr7tm1Fdp/Dhcr7tm1FdpNot Specified
Notes:
(a) Expression levels of the phosphorylated protein vary during development in +/+ samples. However, expression levels of the phosphorylated protein are elevated in the mutant compared with controls at all ages examined.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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