Tg(Thy1-PSEN1)17-2Sqn
Transgene Detail
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| Symbol: |
Tg(Thy1-PSEN1)17-2Sqn |
| Name: |
transgene insertion 17-2, Su Qian |
| MGI ID: |
MGI:4836549 |
| Transgene: |
Tg(Thy1-PSEN1)17-2Sqn Location: unknown
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| Alliance: |
Tg(Thy1-PSEN1)17-2Sqn page
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| Strain of Origin: |
C57BL/6 x SJL
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Thy1-PSEN1)17-2Sqn expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PSEN1 (5663) |
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Mutation details: The human Thy-1 promoter was used to drive expression of a presenilin cDNA. Two lines were examined for their ability to rescue phenotypic defects in presenilin deficient mice. Ability to rescue phenotype differed somewhat but line 17-2 was the better of the two lines and was chosen as representative.
(J:77306)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:77306 Qian S, et al., Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. Neuron. 1998 Mar;20(3):611-7 |
| All: |
2 reference(s) |
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Analysis Tools
