Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkaa1tm1.1Sjm
Name:	protein kinase, AMP-activated, alpha 1 catalytic subunit; targeted mutation 1.1, Sean J Morrison
MGI ID:	MGI:4836199
Synonyms:	AMPKa1fl, Prkaa1fl
Gene:	Prkaa1  Location: Chr15:5173343-5211380 bp, + strand  Genetic Position: Chr15, 1.99 cM
Alliance:	Prkaa1tm1.1Sjm page

Germline Transmission:	Earliest citation of germline transmission: J:165090
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo selection cassette. (J:165090)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkaa1 Mutation:	42 strains or lines available

Original:	J:165090 Nakada D, et al., Lkb1 regulates cell cycle and energy metabolism in hematopoietic stem cells. Nature. 2010;468(7324):653-658
All:	65 reference(s)