Tg(Cela1-IL1B)L123Tcw
Transgene Detail
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| Symbol: |
Tg(Cela1-IL1B)L123Tcw |
| Name: |
transgene insertion L123, Timothy C Wang |
| MGI ID: |
MGI:4454647 |
| Transgene: |
Tg(Cela1-IL1B)L123Tcw Location: unknown
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| Alliance: |
Tg(Cela1-IL1B)L123Tcw page
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| Strain of Origin: |
CBA x C57BL/6
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Cela1-IL1B)L123Tcw expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
IL1B (3553) |
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Mutation details: The rat elastase promoter drives expression of the human interleukin-1beta gene. Expression of the transgene was confirmed in the pancreas by reverse-transcription (RT)-PCR and by enzyme-linked immunosorbent assay (ELISA) measurement of human IL-1beta peptide in pancreatic protein extracts. Expression was not detected in any of the other tissues analyzed, including liver, submaxillary
glands, kidney, lung, and spleen.
(J:142524)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:142524 Marrache F, et al., Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis. Gastroenterology. 2008 Oct;135(4):1277-87 |
| All: |
3 reference(s) |
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Analysis Tools
