Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sec61a1m1Gek
Name:	SEC61 translocon subunit alpha 1; mutation 1, Nicholas Gekakis
MGI ID:	MGI:4830998
Synonyms:	Sec61a1Y344H
Gene:	Sec61a1  Location: Chr6:88480589-88495782 bp, - strand  Genetic Position: Chr6, 39.51 cM
Alliance:	Sec61a1m1Gek page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU mutagenesis induced a T to C transition at codon 344 that results in an amino substitution of histidine for tyrosine at position 344 (Y344H). (J:164159) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sec61a1 Mutation:	16 strains or lines available

Original:	J:164159 Lloyd DJ, et al., A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice. Diabetes. 2010 Feb;59(2):460-70
All:	2 reference(s)