Tg(KRT14-Ptch1)#Abal
Transgene Detail
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| Symbol: |
Tg(KRT14-Ptch1)#Abal |
| Name: |
transgene insertion, Allan Balmain |
| MGI ID: |
MGI:4830587 |
| Synonyms: |
K14PtchFVB |
| Transgene: |
Tg(KRT14-Ptch1)#Abal Location: unknown
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| Alliance: |
Tg(KRT14-Ptch1)#Abal page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(KRT14-Ptch1)#Abal expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Ptch1 (MGI:105373) |
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Mutation details: An HA-tagged Ptch1 sequence from C57BL/6 was modified to encode the Threonine to Asparagine sustitution at amino acid residue 1267 which is found in FVB/N strains. Residue 1267 is found in a conserved region of the cytoplasmic domain near the C-terminus. The modified sequence was placed under the control of the human KRT14 promoter. At least four founder lines were produced (numbers 6, 7, 8, 10).
(J:118622)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:118622 Wakabayashi Y, et al., Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature. 2007 Feb 15;445(7129):761-5 |
| All: |
1 reference(s) |
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Analysis Tools
