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Gon4ljusty
Chemically induced Allele Detail
Summary
Symbol: Gon4ljusty
Name: gon-4 like; justy
MGI ID: MGI:4829629
Gene: Gon4l  Location: Chr3:88742531-88817406 bp, + strand  Genetic Position: Chr3, 39.0 cM
Alliance: Gon4ljusty page
Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a T to A transversion producing a cryptic splice site in intron 24 that results in the production of an expanded transcript. This modified transcript contains 81 additional nucleotides, including two premature stop codons. The absence of protein expression was confirmed by western blot analysis on cell lysates. (J:163412)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gon4l Mutation:  83 strains or lines available
References
Original:  J:163412 Lu P, et al., The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. J Exp Med. 2010 Jul 5;207(7):1359-67
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory