Adam17tm1Srj
Targeted Allele Detail
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| Symbol: |
Adam17tm1Srj |
| Name: |
a disintegrin and metallopeptidase domain 17; targeted mutation 1, Stefan Rose-John |
| MGI ID: |
MGI:4822481 |
| Synonyms: |
ADAM17exneo |
| Gene: |
Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
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| Alliance: |
Adam17tm1Srj page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:163380
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129S/SvEv
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| Allele Type: |
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Targeted (Hypomorph) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: An FRT flanked neo with a 5' loxP site was inserted upstream of exon 11. An artificial exon (11a) was created in intron 11 by inserting a cryptic splice donor site upstream of an existing cryptic acceptor site in intron 11. If spliced in, exon 11a creates a truncated CDS owing to an in-frame stop codon at the 5' end. A loxP site was inserted at the 3' end of exon 11a.
(J:163380)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Adam17 Mutation: |
62 strains or lines available
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| Original: |
J:163380 Chalaris A, et al., Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 2010 Aug 2;207(8):1617-24 |
| All: |
1 reference(s) |
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Analysis Tools
