Adam17tm1.1Srj
Targeted Allele Detail
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Symbol: |
Adam17tm1.1Srj |
Name: |
a disintegrin and metallopeptidase domain 17; targeted mutation 1.1, Stefan Rose-John |
MGI ID: |
MGI:4822480 |
Synonyms: |
ADAM17ex |
Gene: |
Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
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Alliance: |
Adam17tm1.1Srj page
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Germline Transmission: |
Earliest citation of germline transmission:
J:163380
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Conditional ready, Hypomorph) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: An FRT flanked neo with a 5' loxP site was inserted upstream of exon 11. A modified exon 11 (exon 11a) was inserted downstream of the endogenous exon. It contains a stop codon at the 5' end and a loxP site at the 3' end. Flp mediated recombination removed the neo cassette leaving exons 11 and 11a floxed. Severely reduced protein expression was confirmed by western blot analysis on skin and heart extracts. This is a hypomorphic allele.
(J:163380)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Adam17 Mutation: |
62 strains or lines available
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Original: |
J:163380 Chalaris A, et al., Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 2010 Aug 2;207(8):1617-24 |
All: |
24 reference(s) |
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