Tg(Bglap-TGFB2*C226S*C228S)D4Rdk
Transgene Detail
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| Symbol: |
Tg(Bglap-TGFB2*C226S*C228S)D4Rdk |
| Name: |
transgene insertion D4, Rik Derynck |
| MGI ID: |
MGI:4819544 |
| Synonyms: |
D4 |
| Transgene: |
Tg(Bglap-TGFB2*C226S*C228S)D4Rdk Location: unknown
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| Alliance: |
Tg(Bglap-TGFB2*C226S*C228S)D4Rdk page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Bglap-TGFB2*C226S*C228S)D4Rdk expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
TGFB2 (7042) |
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Transgene codes for a protein with two cysteine to serine mutations. |
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Mutation details: A 1.8 kb rat osteocalcin promoter fragment was used to direct expression of a human TGF-beta2 cDNA in osteoblasts. The TGF-beta2 cDNA was modified by two point mutations which changed the cysteines normally found at codons 226 and 228 to serines. Eight founders were produced but only founder lines D4 and D5 where characterized. Homozygotes could not be derived from the D4 founder.
(J:105791)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:105791 Erlebacher A, et al., Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996 Jan;132(1-2):195-210 |
| All: |
2 reference(s) |
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Analysis Tools
