Tg(CD2-Il5)#Ldt
Transgene Detail
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| Symbol: |
Tg(CD2-Il5)#Ldt |
| Name: |
transgene insertion, Lindsay A Dent |
| MGI ID: |
MGI:4819505 |
| Synonyms: |
IL-5Tg |
| Transgene: |
Tg(CD2-Il5)#Ldt Location: unknown
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| Alliance: |
Tg(CD2-Il5)#Ldt page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CD2-Il5)#Ldt expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Il5 (MGI:96557) |
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Mutation details: 10 kb of genomic mouse Il5 sequences under the control of the dominant control region (DCR) from human CD2 was used for the transgene. This region drives thymocyte and T-cell specific expression. Northern blot analysis confirmed transgene expression in the thymus, Peyer's patches and subcutaneous lymph nodes of transgenic animals. Founders Tg5C1 and Tg5C2 carry 8 and 49 copies of the transgene, respectively, and express 65X and 265X the amount of blood eosinophils of nontransgenic littermates, respectively. The symbol # is used when no line is specified or both lines are pooled.
(J:76902)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:161234 Dyer KD, et al., Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. J Immunol. 2010 Jun 1;184(11):6327-34 |
| All: |
12 reference(s) |
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Analysis Tools
