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Tg(SFTPC-TGFA)28Kor
Transgene Detail
Summary
Symbol: Tg(SFTPC-TGFA)28Kor
Name: transgene insertion 28, Thomas R Korfhagen
MGI ID: MGI:4819387
Transgene: Tg(SFTPC-TGFA)28Kor  Location: unknown  
Alliance: Tg(SFTPC-TGFA)28Kor page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SFTPC-TGFA)28Kor expresses 1 gene
 
Mutation detailsThe entire coding region of human TGFA was fused to the human SFTPC promoter and used for the transgene. Introns from the human growth factor gene were included to enhance transgene expression. The transgene is expressed in lung epithelial cells. Lines 2, 4, 28, and 6108 were generated with 3.1-, 2.3-, 4.3-, and 1.3-fold expression, respectively. (J:133163)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:133163 Hardie WD, et al., Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha. Am J Respir Cell Mol Biol. 2002 Apr;26(4):430-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory