Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxa1tm7.1(cre)Mrc
Name:	homeobox A1; targeted mutation 7.1, Mario R Capecchi
MGI ID:	MGI:4818445
Synonyms:	Hoxa1IC, Hoxa1-IRES-Cre
Gene:	Hoxa1  Location: Chr6:52132573-52135299 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance:	Hoxa1tm7.1(cre)Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:160496
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Hoxa1tm7.1(cre)Mrc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Hoxa1 (MGI:96170)   Mutation details: An IRES-cre-FRT-MC1-Neo-FRT cassette was inserted 36 bp downstream of the stop codon of the Hoxa1 gene by recombination in R1 ES cells. Chnmeras were crossed to FLPe deleter mice to remove the neo selection marker. (J:160496)

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxa1 (mouse) Summary of all recombinase alleles driven by Hoxa1. Alliance mouse Hoxa1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:	14 strains or lines available

Original:	J:160496 Makki N, et al., Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. Dev Biol. 2010 May 15;341(2):499-509
All:	2 reference(s)