Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(TNF)#Gkl
Name:	transgene insertion, George Kollias
MGI ID:	MGI:4818267
Transgene:	Tg(TNF)#Gkl  Location: unknown
Alliance:	Tg(TNF)#Gkl page

Strain of Origin:

(CBA x C57BL/6)

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(TNF)#Gkl expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human TNF (7124) Tnf  (MGI:104798)   Mutation details: The transgene comprises the human tumor necrosis factor gene with its 3' UTR, polyadenylation signal and flanking sequence replaced by those of the human hemoglobin beta (HBB) gene. This modification interferes with posttranscriptional regulation of TNF expression, altering expression levels and timing, but apparently not its tissue specificity. This is a representative record for the three founders that produced similar phenotypes (Tg197, Tg1480, Tg1486, carrying about 5, 2, and 10 copies of the transgene, respectively). (J:92576)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:92576 Keffer J, et al., Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 1991 Dec;10(13):4025-31
All:	5 reference(s)