Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Slc2a2-cre)#Thor
Name:	transgene insertion, Bernard Thorens
MGI ID:	MGI:4462802
Synonyms:	pGLUT2-Cre
Transgene:	Tg(Slc2a2-cre)#Thor  Location: unknown
Alliance:	Tg(Slc2a2-cre)#Thor page

Strain of Origin:

(BALB/c x C57BL/6)F2

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Slc2a2-cre)#Thor expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Slc2a2   Mutation details: A cre-polyA-FRT-ampicillin-FRT targeting cassette with Slc2a2 homology fragments and a nuclear localization signal (nls) was inserted by homologous recombination at the ATG site of the Slc2a2 (Glut2) gene in EL250 bacteria. The FRT-ampicillin-FRT cassette was then removed in the presence of arabinose. Six line were obtained and crossed to reporter mice to verify cre activity. Two of these lines gave appropriate expression in pancreatic beta cells, liver, and intestine. Cre activity in the brain was in agreement with reported Slc2a2 expression. No line numbers were specified. (J:162050)

Activity:	Tissue activity of this recombinase allele
Driver:	Slc2a2 (species not specified) Summary of all recombinase alleles driven by Slc2a2.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:162050 Mounien L, et al., Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons. FASEB J. 2010 Jun;24(6):1747-58
All:	3 reference(s)