Tg(Flt3-cre/ERT2)#Ccb
Transgene Detail
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Symbol: |
Tg(Flt3-cre/ERT2)#Ccb |
Name: |
transgene insertion, Conrad C Bleul |
MGI ID: |
MGI:4462357 |
Synonyms: |
Flt3::CreERT2 |
Transgene: |
Tg(Flt3-cre/ERT2)#Ccb Location: unknown
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Alliance: |
Tg(Flt3-cre/ERT2)#Ccb page
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Transgene Type: |
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Transgenic (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Tg(Flt3-cre/ERT2)#Ccb expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Flt3 (MGI:95559) |
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Mutation details: A sequence encoding cre fused to a mutant estrogen ligand binding domain (ERT2) together with an FRT-flanked kanamycin cassette was inserted into a BAC (RP24-145C8) into exon 1 of the Flt3 locus by ET cloning. Negative selection to identify properly targeted colonies was performed by transfection with an Flp recombinase-containing plasmid and selecting for kanamycin-sensitive colonies. Recombination was confirmed by sequencing and properly targeted BACs were injected into C57BL/6 pronuclei. No line numbers were specified.
(J:136220)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Flt3
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:136220 Benz C, et al., The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med. 2008 May 12;205(5):1187-99 |
All: |
4 reference(s) |
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