Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(LRRK2)WT1Mjfa
Name:	transgene insertion WT1, Matthew Farrer
MGI ID:	MGI:4460657
Synonyms:	hWT, LRRK2 WT
Transgene:	Tg(LRRK2)WT1Mjfa  Location: unknown  Genetic Position: Chr12, Syntenic
Alliance:	Tg(LRRK2)WT1Mjfa page

Strain of Origin:

FVB/NTac

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(LRRK2)WT1Mjfa expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human LRRK2 (120892) Lrrk2  (MGI:1913975)   Mutation details: These transgenic mice express the human LRRK2 gene with high levels of protein detected, with an expression pattern similar to that of endogenous mouse Lrrk2. The transgene inserted into Chromosome 12. Transgenic mice express human LRRK2 approximately 20-22 fold over the endogenous mouse Lrrk2 level. Line WT1 was generated. (J:161656)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:161656 Farrer MJ, et al., LRRK2 WT BAC transgenic strain. MGI Direct Data Submission. 2010;
All:	7 reference(s)