Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Irf6clft1 Name: interferon regulatory factor 6; cleft palate 1 MGI ID: MGI:4457055 Gene: Irf6  Location: Chr1:192835419-192854331 bp, + strand  Genetic Position: Chr1, 97.6 cM Alliance: Irf6clft1 page

Palatal defects in Irf6clft1/Irf6clft1 mice Show the 4 phenotype image(s) involving this allele.

Strain of Origin:

A/J

Allele Type:    Chemically induced (ENU) (Hypomorph) Mutation:    Single point mutation   Mutation details: ENU mutagenesis induced a C to T transition that results in the amino acid substitution of proline with leucine at position 39 (P39L). This allele is hypomorphic. (J:160190)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf6 Mutation:	26 strains or lines available

Original:	J:160190 Stottmann RW, et al., Identification of a Van der Woude syndrome mutation in the cleft palate 1 mutant mouse. Genesis. 2010 May;48(5):303-8
All:	2 reference(s)