Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sema3am808Ddg
Name:	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; mutation 808, David D Ginty
MGI ID:	MGI:4455203
Synonyms:	Sema3AK108N
Gene:	Sema3a  Location: Chr5:13175381-13652533 bp, + strand  Genetic Position: Chr5, 4.31 cM
Alliance:	Sema3am808Ddg page

Strain of Origin:

C57BL/6

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU mutagenesis induced an A to T transversion at position that results in the amino acid substitution of asparagine for lysine at position 108 (K108N). The protein product is predicted to poorly interact with the Npn-1/PlexA holoreceptor. (J:159834)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sema3a Mutation:	47 strains or lines available

Original:	J:159834 Merte J, et al., A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. J Neurosci. 2010 Apr 21;30(16):5767-75
All:	9 reference(s)