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Gene Expression Data
Assay Details
Assay
Reference: J:158294 Abdollahi MR, et al., Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia. Am J Hum Genet. 2009 Nov;85(5):737-44
Assay type: RNA in situ
MGI Accession ID: MGI:4453037
Gene symbol: Tuba8
Gene name: tubulin, alpha 8
Probe: Tuba8 cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 4A,F: embryonic day 13.5 (more )
Note: (F-J) are higher magnifications of the boxed areas in (A-E).
Structure Level Pattern Image Note
TS21: telencephalon Strong Regionally restricted 4F , 4A Expression is in the postmitotic layers of the telencephalon.
TS21: cerebral cortex Strong Regionally restricted 4A , 4F Expression is in the dorsal cortex and cingulate cortex.
TS21: ganglionic eminence Present 4A , 4F Expression is also in migratory cells of the subventricular zone/mantle zone of the ganglionic eminence.

Specimen 4B,G: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cortical plate Strong 4G , 4B
TS23: cerebral cortex Strong Regionally restricted 4B , 4G Expression is in the dorsal cortex, perirhinal cortex, and cingulate cortex.
TS23: ganglionic eminence Strong 4G , 4B
TS23: cerebral cortex intermediate zone Present 4B , 4G
TS23: cerebral cortex subventricular zone Present 4B , 4G

Specimen 4C,H: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral cortex ventricular zone Very strong 4C , 4H
TS26: cortical subplate Very strong 4C , 4H
TS26: cerebral cortex Very strong Regionally restricted 4H , 4C Expression is in the upper layers, less in the putative layer VI. Expression is in the dorsdal cortex and perirhinal cortex.
TS26: piriform cortex Present 4C , 4H

Specimen 4D,I: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: neocortex layer Present Regionally restricted 4I , 4D Expression is in the layer of still migrating cortical neurons of the dense cortical plate and subplate.
TS27: medial dorsal thalamic nucleus Present 4D , 4I
TS27: perirhinal cortex Present 4D , 4I

Specimen 4E,J: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: neocortex layer Strong Regionally restricted 4J , 4E Expression is in the subplate.
TS28: cortical layer II Strong 4J , 4E
TS28: cortical layer III Strong 4J , 4E
TS28: cortical layer V Strong 4J , 4E
TS28: main olfactory bulb mitral cell layer Present 4E , 4J
TS28: medial dorsal thalamic nucleus Present 4E , 4J

Specimen 4K: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: hippocampus Present Regionally restricted 4K Expression is in the pyramidal layer.
TS23: hypothalamus Present 4K

Specimen 4L: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: hippocampus CA1 Strong 4L
TS26: hippocampus CA2 Strong 4L
TS26: hippocampus CA3 Strong 4L
TS26: dentate gyrus Present 4L

Specimen 4M: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: hippocampus CA1 Very strong 4M
TS27: hippocampus CA2 Very strong 4M
TS27: hippocampus CA3 Very strong 4M
TS27: dentate gyrus Strong 4M

Specimen 4N: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Strong 4N
TS28: dentate gyrus Present 4N
TS28: hippocampus Present 4N

Specimen 4O: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present Regionally restricted 4O Expression is in the inner part.
TS28: cerebellum molecular layer Present 4O
TS28: cerebellum internal granule cell layer Weak 4O


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory