Tg(Thy1-DCTN2)M21Elfh
Transgene Detail
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| Symbol: |
Tg(Thy1-DCTN2)M21Elfh |
| Name: |
transgene insertion M21, Erika Holzbaur |
| MGI ID: |
MGI:4354272 |
| Synonyms: |
Tgdynamitin, transgenic M21 |
| Transgene: |
Tg(Thy1-DCTN2)M21Elfh Location: unknown
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| Alliance: |
Tg(Thy1-DCTN2)M21Elfh page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Thy1-DCTN2)M21Elfh expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
DCTN2 (10540) |
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Mutation details: The Thy1.2 promoter drives expression of a human dynamitin (DCTN2) cDNA, with a FLAG tag added to the 3' terminus of the coding sequences, in postnatal motor neurons. The M21 line was estimated to have a ~20-fold increase in dynamitin mRNA levels. Expression of the encoded protein in brain homogenates by western blot using FLAG-tag antibodies is not detected until postnatal day 13. Two additional lines (M5 and M13) were created and these had ~2- to 4-fold increased levels of dynamitin mRNA, respectively.
(J:130629)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:130629 LaMonte BH, et al., Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron. 2002 May 30;34(5):715-27 |
| All: |
3 reference(s) |
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Analysis Tools
