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Tg(Nphs1-Actn4*K256E)1Crjk
Transgene Detail
Summary
Symbol: Tg(Nphs1-Actn4*K256E)1Crjk
Name: transgene insertion 1, Chris Kennedy
MGI ID: MGI:4443334
Transgene: Tg(Nphs1-Actn4*K256E)1Crjk  Location: unknown  
Alliance: Tg(Nphs1-Actn4*K256E)1Crjk page
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Nphs1-Actn4*K256E)1Crjk expresses 1 gene
 
Mutation detailsThe Nphs1 promoter was used to drive expression of mouse Actn4 cDNA in podocytes. The Actn4 cDNA contains a mutation resulting in a lysine to glutamic acid substitution at residue 256. (J:132794)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:132794 Michaud JL, et al., Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant alpha-actinin-4. J Am Soc Nephrol. 2003 May;14(5):1200-11
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory