Med1tm2Rgr
Targeted Allele Detail
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Symbol: |
Med1tm2Rgr |
Name: |
mediator complex subunit 1; targeted mutation 2, Robert G Roeder |
MGI ID: |
MGI:4443002 |
Synonyms: |
MED1KI |
Gene: |
Med1 Location: Chr11:98042980-98084119 bp, - strand Genetic Position: Chr11, 61.75 cM, cytoband D
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Alliance: |
Med1tm2Rgr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:159303
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Intragenic deletion, Nucleotide substitutions
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Mutation details: Exons 5 through 8 were replaced with a cDNA in which nucleotide substitutions resulted in the amino acid substitution of alanine for lysine within the LxxLL motif (to LxxAA). A floxed neo cassette was inserted for selection purposes. Normal levels of protein expression were confirmed by western blot analysis.
(J:159303)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Med1 Mutation: |
83 strains or lines available
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Original: |
J:159303 Jiang P, et al., Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6765-70 |
All: |
3 reference(s) |
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