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Med1tm2Rgr
Targeted Allele Detail
Summary
Symbol: Med1tm2Rgr
Name: mediator complex subunit 1; targeted mutation 2, Robert G Roeder
MGI ID: MGI:4443002
Synonyms: MED1KI
Gene: Med1  Location: Chr11:98042980-98084119 bp, - strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance: Med1tm2Rgr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159303
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion, Nucleotide substitutions
 
Mutation detailsExons 5 through 8 were replaced with a cDNA in which nucleotide substitutions resulted in the amino acid substitution of alanine for lysine within the LxxLL motif (to LxxAA). A floxed neo cassette was inserted for selection purposes. Normal levels of protein expression were confirmed by western blot analysis. (J:159303)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Med1 Mutation:  83 strains or lines available
References
Original:  J:159303 Jiang P, et al., Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6765-70
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory