Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Daglatm1Pado
Name:	diacylglycerol lipase, alpha; targeted mutation 1, Patrick Doherty
MGI ID:	MGI:4438719
Gene:	Dagla  Location: Chr19:10222629-10282241 bp, - strand  Genetic Position: Chr19, 6.55 cM
Alliance:	Daglatm1Pado page

Germline Transmission:	Earliest citation of germline transmission: J:157850
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 1 was replaced by a GFP-Neo selection cassette by homologous recombination. Absence of RNA and protein was confirmed by quantitative RT-PCR and western blot analysis of cerebellum extracts. (J:157850)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dagla Mutation:	60 strains or lines available

Original:	J:157850 Gao Y, et al., Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci. 2010 Feb 10;30(6):2017-24
All:	7 reference(s)