Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(HTT*97Q)LXwy
Name:	transgene insertion L, X William Yang
MGI ID:	MGI:4438228
Synonyms:	BACHD-L
Transgene:	Tg(HTT*97Q)LXwy  Location: unknown
Alliance:	Tg(HTT*97Q)LXwy page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(HTT*97Q)LXwy expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human HTT (3064) Htt  (MGI:96067)   Mutation details: The 240 kb human bacterial artificial chromosome BAC(RP11-866L6), containing the entire 170 kb human Huntingtin (htt) genomic locus and approximately 20 kbp of 5' and 50 kbp of 3' flanking sequences, was modified by replacing the human htt exon 1 with a loxP-flanked human mutant htt exon 1 sequence (containing 97 mixed CAA-CAG repeats encoding a continuous polyglutamine (polyQ) stretch). Two lines were created (line I and L) that exhibit the same phenotype. (J:137345)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:137345 Gray M, et al., Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci. 2008 Jun 11;28(24):6182-95
All:	8 reference(s)