Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Cck-cre)CKres
Name:	transgene insertion C, Kerry J Ressler
MGI ID:	MGI:4438218
Synonyms:	CCID, CCK-Cre, CCK-Cre-IRES-DsRed2
Transgene:	Tg(Cck-cre)CKres  Location: unknown
Alliance:	Tg(Cck-cre)CKres page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Cck-cre)CKres expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Cck   Mutation details: The coding sequence for cre recombinase, followed by an IRES and the DsRed2 sequence was placed downstream of a 3kb cholecystokinin (CCK) promoter. The construct was linearized, purified, and microinjected into the pronuclei of one-cell C57BL/6 embryos. Lines A, B, and C were established and analyzed. None of the three lines showed any observable DsRed fluorescence. Line C showed high levels of cre expression in the cortex, in a manner qualitatively similar to observed patterns of endogenous Cck mRNA expression, but showed almost no cre-mediated LacZ expression in any subcortical regions. (J:154361)

Activity:	Tissue activity of this recombinase allele
Driver:	Cck (species not specified) Summary of all recombinase alleles driven by Cck. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:154361 Chhatwal JP, et al., Identification of cell-type-specific promoters within the brain using lentiviral vectors. Gene Ther. 2007 Apr;14(7):575-83
All:	4 reference(s)