Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Th-ALPP)1Erav
Name:	transgene insertion 1, Elio Raviola
MGI ID:	MGI:4436729
Synonyms:	THpPLAP
Transgene:	Tg(Th-ALPP)1Erav  Location: unknown
Alliance:	Tg(Th-ALPP)1Erav page

Strain of Origin:

(C57BL/6 x SJL/J)F2

Transgene Type:    Transgenic (Reporter) Mutation:    Insertion   Tg(Th-ALPP)1Erav expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human ALPP (250) Alpi  (MGI:1924018)   Tg(Th-ALPP)1Erav expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Th (25085) Th  (MGI:98735)   Mutation details: The THpPLAP transgene was designed with the human Placental Alkaline Phosphatase (ALPP or hPLAP) gene driven by a rat tyrosine hydroxylase (TH) promoter, a simian virus 40 (SV40) intervening sequence, and SV40 polyadenylation site. This line contains 50 copies of the transgene. PLAP intensely labels the outer surface of the cell membrane of TH-expressing dopamine (DA) releasing, catecholaminergic amacrines of the retina and the dopaminergic neurons of the brain, including those of the substantia nigra, VTA and olfactory bulb. Furthermore they label, less intensely, the neurons of the locus coeruleus (norepinephrine) and, weakly, the type 2 catecholaminergic amacrines of the retina (transmitter unknown). (J:157684)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:157684 Gustincich S, et al., Control of dopamine release in the retina: a transgenic approach to neural networks. Neuron. 1997 May;18(5):723-36
All:	2 reference(s)