Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Klf5tm2.1Rng Name: Kruppel-like transcription factor 5; targeted mutation 2.1, Ryozo Nagai MGI ID: MGI:4421792 Synonyms: Klf5fl Gene: Klf5  Location: Chr14:99536127-99550848 bp, + strand  Genetic Position: Chr14, 49.43 cM, cytoband E2.1 Alliance: Klf5tm2.1Rng page

Fibroblast-specific deletion of Klf5 attenuates cardiac hypertrophy and fibrosis after TAC in Klf5tm2.1Rng/Klf5tm2.1Rng Tg(Postn-cre)1Sjc mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:156696
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2 and a neo cassette flanked by loxP and frt sites was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:156696)

Generation of the Klf5tm2.1Rng allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf5 Mutation:	37 strains or lines available

Original:	J:156696 Takeda N, et al., Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest. 2010 Jan;120(1):254-65
All:	15 reference(s)