Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Ppp1r2-cre)4127Nkza
Name:	transgene insertion 4127, Kazu Nakazawa
MGI ID:	MGI:4421503
Synonyms:	Cre #4127, Ppp1r2-cre
Transgene:	Tg(Ppp1r2-cre)4127Nkza  Location: unknown
Alliance:	Tg(Ppp1r2-cre)4127Nkza page

Strain of Origin:

C57BL/6N

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Ppp1r2-cre)4127Nkza expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Ppp1r2 (MGI:1914099)   Mutation details: BAC homologous recombination was used to insert cre cDNA (fused with a nuclear localization signal (NLS) sequence) immediately upstream of the initiation codon of the Ppp1r2 gene in BAC RPCI-24-322B4. The cre cDNA was followed by the bovin growth hormone-derived polyadenylation signal. In one clone, a 12-kb deletion introduced around the initial methionine codon of the apolipoprotein D (Apod) coding sequence, located 50 kb upstream of Ppp1r2, was identified. This clone was used to prevent overexpression of Apod in the brain of transgenic mice. (J:156785)

Activity:	Tissue activity of this recombinase allele
Driver:	Ppp1r2 (mouse) Summary of all recombinase alleles driven by Ppp1r2. Comparative matrix view of recombinase activities Alliance mouse Ppp1r2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:156785 Belforte JE, et al., Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci. 2010 Jan;13(1):76-83
All:	11 reference(s)