Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(tetO-SNCA*A53T)E2Cai
Name:	transgene insertion E2, Huaibin Cai
MGI ID:	MGI:4420801
Synonyms:	alpha-syn A53T, tetO-A53T
Transgene:	Tg(tetO-SNCA*A53T)E2Cai  Location: unknown
Alliance:	Tg(tetO-SNCA*A53T)E2Cai page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-SNCA*A53T)E2Cai expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SNCA (6622) Snca  (MGI:1277151)   Mutation details: A transgenic vector was generated encoding a human SNCA*A53T mutant gene under the control of a tetO promoter. The construct was microinjected into C57BL/6J fertilized oocytes, and founder mice were bred to C57BL/6J mice to establish the E2 line. (J:156512)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:156512 Lin X, et al., Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24;64(6):807-27
All:	16 reference(s)