Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Aqp4-cre/ERT2)55-27Fwp
Name:	transgene insertion 55-27, Frank W Pfrieger
MGI ID:	MGI:4420275
Synonyms:	Tg(Aqp4-CreERT2)5527
Transgene:	Tg(Aqp4-cre/ERT2)55-27Fwp  Location: unknown
Alliance:	Tg(Aqp4-cre/ERT2)55-27Fwp page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Aqp4-cre/ERT2)55-27Fwp expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Aqp4 (MGI:107387)   Mutation details: The creERT2 expression cassette, preceded by a rabbit beta-globin DNA encompassing intron 2 (beta-globin intervening sequences [bGIVS]) and followed by the SV40 polyA signal and a PGK/Tn5-driven neomycin resistance cassette flanked by FRT sites (neo) was inserted by homologous recombination at the transcription initiation site of the Aqp4 gene located in BAC RP23-189N2. The linearized vector was injected into pronuclei of fertilized FVB/N eggs. In line 55-27, cre/ERT2 mRNA was detected in similar brain regions as Aqp4 but at much lower concentrations. (J:156087)

Activity:	Tissue activity of this recombinase allele
Driver:	Aqp4 (mouse) Summary of all recombinase alleles driven by Aqp4. Alliance mouse Aqp4 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:156087 Slezak M, et al., Transgenic mice for conditional gene manipulation in astroglial cells. Glia. 2007 Nov 15;55(15):1565-76
All:	1 reference(s)