Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Thy1-PTGS2)300Kand
Name:	transgene insertion 300, Katrin Andreasson
MGI ID:	MGI:4418979
Synonyms:	hCOX-2 tg, Thy-1-COX-2 tg line 300
Transgene:	Tg(Thy1-PTGS2)300Kand  Location: unknown
Alliance:	Tg(Thy1-PTGS2)300Kand page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Thy1-PTGS2)300Kand expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human PTGS2 (5743) Ptgs2  (MGI:97798)   Mutation details: The transgene construct contains the entire 1.8 kb human COX-2 (PTGS2; prostaglandin-endoperoxide synthase 2 or PGE2) open reading frame sequence inserted into the 8.2 kb Thy-1 expression cassette. This construct was injected into the male pronuclei of C57BL/6J cells. No founder lines were provided in the original reference but lines 300, 303, and 316 were characterized in subsequent publications. Mice from founder line 300 were found to have an approximately 10-12-fold increase in PGE2 expression. (J:72034)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:72034 Andreasson KI, et al., Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci. 2001 Oct 15;21(20):8198-209
All:	7 reference(s)