Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Thy1-PTGS2)303Kand
Name:	transgene insertion 303, Katrin Andreasson
MGI ID:	MGI:4418980
Synonyms:	hCOX-2 tg, Thy-1-COX-2 tg line 303
Transgene:	Tg(Thy1-PTGS2)303Kand  Location: unknown
Alliance:	Tg(Thy1-PTGS2)303Kand page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Thy1-PTGS2)303Kand expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human PTGS2 (5743) Ptgs2  (MGI:97798)   Mutation details: The transgene construct contains the entire 1.8 kb human COX-2 (PTGS2; prostaglandin-endoperoxide synthase 2 or PGE2) open reading frame sequence inserted into the 8.2 kb Thy-1 expression cassette. This construct was injected into the male pronuclei of C57BL/6J cells. No founder lines were provided in the original reference but lines 300, 303, and 316 were characterized in subsequent publications. Mice from founder line 303 were found to have an approximately 25-40-fold increase in PGE2 expression. (J:72034)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:72034 Andreasson KI, et al., Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci. 2001 Oct 15;21(20):8198-209
All:	5 reference(s)