Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(CD68-rtTA2S*M2)3Mpil
Name:	transgene insertion 3, Manoj M Pillai
MGI ID:	MGI:4418488
Synonyms:	CD68-MP3, CD68-rtTA, CD68-rtTA-M2
Transgene:	Tg(CD68-rtTA2S*M2)3Mpil  Location: unknown  Genetic Position: Chr1, Syntenic
Alliance:	Tg(CD68-rtTA2S*M2)3Mpil page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Transactivator) Mutation:    Insertion   Mutation details: The CD68-rtTA-M2 transgene was designed with a 2.9 kb promoter sequence from the human CD68 gene followed by a 83 bp fist intron (IVIS), a modified reverse tetracycline-regulated transactivator (rtTA) gene (from plasmid pUHRT-62-1), and bovine growth hormone polyA tail. This 4.5 kb transgene was microinjected into the male pronuclei of two cell (C57BL/6 x CBA) mouse zygotes. Founder line 3 (CD68-MP3) was established and backcrossed to C57BL/6 mice for at least 11 generations. The insertion site has been mapped to Chr 1. (J:154457)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:154457 Pillai MM, et al., Inducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80 - and CSF-1R-expressing populations. Exp Hematol. 2009 Dec;37(12):1387-92
All:	5 reference(s)